TY - JOUR
T1 - Surgical treatment of meningiomas improves neurocognitive functioning and quality of life - a prospective single-center study
AU - Ueberschaer, Moritz
AU - Hackstock, Rene
AU - Rainer, Lucas
AU - Breitkopf, Katharina
AU - Rezai, Arwin
AU - Kaiser, Andreas
AU - Griessenauer, Christoph J.
AU - Schwartz, Christoph
N1 - Ueberschaer, Rezai, Griessenauer, Schwartz: Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria; Hackstock, Kaiser: Institut for Clinical Psychology, Department of Psychiatry,
Psychotherapy and Psychosomatics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria; Rainer: Department of Child and Adolescent Psychiatry, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria; Rainer, Breitkopf: Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Member of the European Reference Network EpiCARE, Salzburg, Austria;
Breitkopf hat kein PURE-Profil → mail an die Editorinnen der Neurologie
PY - 2024/10/10
Y1 - 2024/10/10
N2 - Background and purposeEarly diagnosis and the refinement of treatment of patients with intracranial meningiomas have brought quality of life (QoL) and neurocognitive functioning as outcome measures into focus. The aim of this study is a comprehensive assessment of neurocognitive function, quality of life and the presence of depression in meningioma patients before and after surgery.MethodsPatients with MRI diagnosis of intracranial meningioma and indication for surgery were prospectively included. A clinical neuropsychologist performed neurocognitive assessments within 3 months before and 12 months after surgery. The test battery included investigation of selective and divided attention, verbal and figural memory, executive functioning, and word fluency. Self-report questionnaires to assess depressive symptoms, QoL, and disease coping were administered. Raw values and t-values were compared pre-and postoperatively. Outcome was stratified by tumor- and peritumoral brain edema (PTBE) volumes, postoperative resolution of PTBE and WHO grade. The study included 18 predominantly female patients (83%) with a median age of 59 years and mostly CNS WHO grade 1 meningiomas (83%).ResultsThere was a significant postoperative improvement in the ability to selectively react under stress, in working memory and improved delayed reproduction of verbal and visual memory content. QoL improved regarding a reduction in physical problems, an improvement in energy, and social functioning. There was a trend towards worse preoperative scores in all tests, and greater postoperative improvement in patients with PTBE. Tumor volume had no effect on the measured outcome. The patients did not suffer from depressive symptoms before the surgery but improved postoperatively and most patients had an active, problem-oriented coping strategy.ConclusionResection of intracranial meningiomas leads to an improvement in multiple neurocognitive domains and QoL. There is a trend towards poorer preoperative neurocognitive functioning and greater postoperative improvement in patients with PTBE. Depression appears to play a minor role in the context of neurocognitive functioning and disease coping.
AB - Background and purposeEarly diagnosis and the refinement of treatment of patients with intracranial meningiomas have brought quality of life (QoL) and neurocognitive functioning as outcome measures into focus. The aim of this study is a comprehensive assessment of neurocognitive function, quality of life and the presence of depression in meningioma patients before and after surgery.MethodsPatients with MRI diagnosis of intracranial meningioma and indication for surgery were prospectively included. A clinical neuropsychologist performed neurocognitive assessments within 3 months before and 12 months after surgery. The test battery included investigation of selective and divided attention, verbal and figural memory, executive functioning, and word fluency. Self-report questionnaires to assess depressive symptoms, QoL, and disease coping were administered. Raw values and t-values were compared pre-and postoperatively. Outcome was stratified by tumor- and peritumoral brain edema (PTBE) volumes, postoperative resolution of PTBE and WHO grade. The study included 18 predominantly female patients (83%) with a median age of 59 years and mostly CNS WHO grade 1 meningiomas (83%).ResultsThere was a significant postoperative improvement in the ability to selectively react under stress, in working memory and improved delayed reproduction of verbal and visual memory content. QoL improved regarding a reduction in physical problems, an improvement in energy, and social functioning. There was a trend towards worse preoperative scores in all tests, and greater postoperative improvement in patients with PTBE. Tumor volume had no effect on the measured outcome. The patients did not suffer from depressive symptoms before the surgery but improved postoperatively and most patients had an active, problem-oriented coping strategy.ConclusionResection of intracranial meningiomas leads to an improvement in multiple neurocognitive domains and QoL. There is a trend towards poorer preoperative neurocognitive functioning and greater postoperative improvement in patients with PTBE. Depression appears to play a minor role in the context of neurocognitive functioning and disease coping.
KW - Depression
KW - Meningioma
KW - Neurocognitive testing
KW - Neuropsychology
KW - Quality of life
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pmu_pure&SrcAuth=WosAPI&KeyUT=WOS:001329913100002&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1007/s00701-024-06295-5
DO - 10.1007/s00701-024-06295-5
M3 - Original Article
C2 - 39387938
SN - 0001-6268
VL - 166
JO - ACTA NEUROCHIRURGICA
JF - ACTA NEUROCHIRURGICA
IS - 1
M1 - 402
ER -