@article{389bd94ed7214256acce4d2e24606438,
title = "Prevalence and Characteristics of Metabolic Hyperferritinemia in a Population-Based Central-European Cohort",
abstract = "BACKGROUND: Hyperferritinemia (HF) is a common finding and can be considered as metabolic HF (MHF) in combination with metabolic diseases. The definition of MHF was heterogenous until a consensus statement was published recently. Our aim was to apply the definition of MHF to provide data on the prevalence and characteristics of MHF in a Central-European cohort.METHODS: This study was a retrospective analysis of the Paracelsus 10,000 study, a population-based cohort study from the region of Salzburg, Austria. We included 8408 participants, aged 40-77. Participants with HF were divided into three categories according to their level of HF and evaluated for metabolic co-morbidities defined by the proposed criteria for MHF.RESULTS: HF was present in 13% (n = 1111) with a clear male preponderance (n = 771, 69% of HF). Within the HF group, 81% (n = 901) of subjects fulfilled the metabolic criteria and were defined as MHF, of which 75% (n = 674) were characterized by a major criterion. In the remaining HF cohort, 52% (n = 227 of 437) of subjects were classified as MHF after application of the minor criteria.CONCLUSION: HF is a common finding in the general middle-aged population and the majority of cases are classified as MHF. The new classification provides useful criteria for defining MHF.",
keywords = "Fatty liver disease, Insulin resistance, Masld, Metabolic hyperferritinemia, Metabolic syndrome, Serum ferritin",
author = "Sophie Gensluckner and Bernhard Wernly and Florian Koutny and Georg Strebinger and Stephan Zandanell and Lars Stechemesser and Bernhard Paulweber and Bernhard Iglseder and Eugen Trinka and Vanessa Frey and Patrick Langthaler and Georg Semmler and Luca Valenti and Elena Corradini and Christian Datz and Elmar Aigner",
note = "Lehr-KH Oberndorf; Genslucker, Strebinger, Zandanell, Stechemesser, Paulweber, Aigner: Department of Internal Medicine I, Paracelsus Medical University, M{\"u}llner Hauptstrasse 48, 5020 Salzburg, Austria; Gensluckner, Strebinger, Zandanell, Stechemesser, Aigner: Obesity Research Unit, Paracelsus Medical University, M{\"u}llner Hauptstrasse 48, 5020 Salzburg, Austria; Wernly, Datz: Department of Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University, Paracelsusstra{\ss}e 37, 5110 Oberndorf, Austria; Iglseder: Department of Geriatric Medicine, Christian Doppler University Hospital, Paracelsus Medical University, Ignaz-Harrer-Stra{\ss}e 79, 5020 Salzburg, Austria; Trinka, Frey, Langthaler: Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Affiliated Member of the European Reference Network EpiCARE, Ignaz-Harrer-Stra{\ss}e 79, 5020 Salzburg, Austria",
year = "2024",
month = jan,
day = "17",
doi = "10.3390/biomedicines12010207",
language = "English",
volume = "12",
journal = "BIOMEDICINES",
issn = "2227-9059",
publisher = "MDPI",
number = "1",
}