@article{45b012578d954c8d98a23464d3ad6106,
title = "Iron, Oxidative Stress, and Metabolic Dysfunction-Associated Steatotic Liver Disease",
abstract = "Excess free iron is a substrate for the formation of reactive oxygen species (ROS), thereby augmenting oxidative stress. Oxidative stress is a well-established cause of organ damage in the liver, the main site of iron storage. Ferroptosis, an iron-dependent mechanism of regulated cell death, has recently been gaining attention in the development of organ damage and the progression of liver disease. We therefore summarize the main mechanisms of iron metabolism, its close connection to oxidative stress and ferroptosis, and its particular relevance to disease mechanisms in metabolic-dysfunction-associated fatty liver disease and potential targets for therapy from a clinical perspective.",
keywords = "iron metabolism, oxidative stress, ferroptosis, MASLD, liver fibrosis, HEPATOCELLULAR-CARCINOMA, CELL-DEATH, FERROPTOSIS, OVERLOAD, ACTIVATION, FIBROSIS, DYSREGULATION, HOMEOSTASIS, INJURY, Oxidative stress, Iron metabolism, Ferroptosis, Liver fibrosis, Masld",
author = "S Gensluckner and B Wernly and C Datz and E Aigner",
note = "Lerh-KH Oberndorf; Gensluckner, Aigner: Department of Internal Medicine I, Paracelsus Medical University, M{\"u}llner Hauptstrasse 48, 5020 Salzburg, Austria; Obesity Research Unit, Paracelsus Medical University, 5020 Salzburg, Austria; Wernly, Datz: Department of Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University, 5110 Oberndorf, Austria ",
year = "2024",
month = feb,
day = "7",
doi = "10.3390/antiox13020208",
language = "English",
volume = "13",
journal = "Antioxidants",
issn = "2076-3921",
publisher = "MDPI",
number = "2",
}