Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance

F Kalantari, N Mohseninia, A Wetsch, S Harsini, L Hehenwarter (Co-Autor/-in), G Schweighofer-Zwink (Co-Autor/-in), N Zamani-Siahkali, G Rendl (Co-Autor/-in), M Beheshti (Co-Autor/-in), C Pirich* (Letztautor/-in)

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in FachzeitschriftOriginalarbeit (Zeitschrift)Begutachtung

Abstract

Background: Myocardial perfusion imaging (MPI) plays a crucial role in diagnosing coronary artery disease (CAD), with single-photon emission computed tomography (SPECT) being a widely accepted method. The accuracy of MPI relies on image quality and the expertise of physicians. While CZT-SPECT cameras offer advantages, they can be susceptible to attenuation artifacts. Therefore, our objective was to evaluate the diagnostic accuracy of CZT-SPECT and SPECT/CT in a clinical setting. Method: We conducted a prospective single-center study involving patients with known or suspected stable ischemic heart disease who underwent SPECT-MPI using CZT-SPECT and SPECT/CT scanners, and the latter was equipped with cardiofocal collimation. Experienced physicians performed analysis and reporting based on automated quantification and visual image interpretation. Results: A total of 77 patients (32 women (41.6%) and 45 men (58.4%) with an average age of 71.9 & PLUSMN; 8.9 years) were included. The agreement between readers regarding the final conclusion based on imaging reporting using both devices was very high (Kappa 0.87-0.93). Per-vessel analysis revealed a trend suggesting that CZT-SPECT was superior to conventional SPECT/CT in terms of sensitivity, positive predictive value (PPV), negative predictive value (NPV), and accuracy, although the difference did not reach statistical significance. Conclusion: Our study demonstrated that CZT-SPECT imaging offers comparable diagnostic accuracy, improved patient comfort, and eliminates CT-induced radiation compared to SPECT/CT. These findings suggest that cardiac CZT-SPECT imaging has the potential to become a valuable imaging modality in clinical practice.
OriginalspracheEnglisch
Aufsatznummer1879
Seitenumfang12
FachzeitschriftLIFE-BASEL
Jahrgang13
Ausgabenummer9
DOIs
PublikationsstatusVeröffentlicht - Sept. 2023

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