Genetic relationship between rheumatoid arthritis and cardiovascular diseases: A systematic review of Mendelian randomization studies

Mathias Ausserwinkler (Erstautor/-in), Sophie Gensluckner (Co-Autor/-in), Andreas Voelkerer, Jens Thiel, Hans-Joerg Neumann, Maria Flamm (Co-Autor/-in), Christian Datz, Elmar Aigner (Co-Autor/-in), Bernhard Wernly* (Letztautor/-in)

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in FachzeitschriftÜbersichtsarbeitBegutachtung

Abstract

ObjectiveRheumatoid arthritis (RA) is recognized as a chronic autoimmune disorder with systemic inflammation and joint damage. Its potential role as a risk factor for cardiovascular diseases (CVD) is increasingly noted. This review delves into the causal relationship between RA and CVD, with Mendelian randomization (MR) offering a genetic perspective.MethodsAn extensive search was conducted in PubMed, Cochrane and Web of Science to identify MR studies addressing the RA-CVD link. Out of 530 studies, 9 met the inclusion criteria, which were rigorously assessed using a critical appraisal checklist. These were further stratified by a sensitivity analysis into categories reflecting the strength of their evidence, from not evaluable to robust.ResultsFrom the nine included studies, eight supported a causal association between RA and an increased risk of CVD, specifically coronary artery disease (CAD) and one did not support a link between RA and heart failure. The results suggest that genetic factors associated with RA may contribute to an elevated risk for CVD. Chronic inflammation, prevalent in RA, emerges as a key mediator in this connection.ConclusionThe systematic review corroborates a genetic causal link between RA and CVD, as evidenced by eight of the nine MR studies reviewed. This suggests a need for integrated cardiovascular risk management in the treatment of RA patients. The findings advocate considering anti-inflammatory treatment that can reduce cardiovascular risk. The overarching evidence signifies a potential direction for new therapeutic strategies aimed at enhancing cardiovascular health in RA patients.
OriginalspracheEnglisch
Seitenumfang7
FachzeitschriftWIENER KLINISCHE WOCHENSCHRIFT
Frühes Online-DatumJuli 2024
DOIs
PublikationsstatusVeröffentlicht - 26 Juli 2024

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