TY - JOUR
T1 - Fertility and abortion
T2 - A population-based comparison between women with cancer and those in childbearing age
AU - Maraschini, Alice
AU - Corsi Decenti, Edoardo
AU - Donati, Serena
AU - Francisci, Silvia
AU - Lopez, Tania
AU - Amodio, Rosalba
AU - Bianconi, Fortunato
AU - Bovo, Emanuela
AU - Bruni, Rossella
AU - Castaing, Marine
AU - Cirilli, Claudia
AU - De Vincenzo, Rosa Pasqualina
AU - Furgiuele, Giuseppe
AU - Guarda, Linda
AU - Iacovacci, Silvia
AU - Mangone, Lucia
AU - Mazzucco, Walter
AU - Melcarne, Anna
AU - Merlo, Elisabetta
AU - Mian, Michael
AU - Sampietro, Giuseppe
AU - Scambia, Giovanni
AU - Scuderi, Tiziana
AU - Sferrazza, Ausilia
AU - Stracci, Fabrizio
AU - Torrisi, Antonina
AU - Trojano, Vito
AU - Vitale, Maria Francesca
AU - Pierannunzio, Daniela
N1 - Lehr-KH , Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medizinischen Privatuniversität (PMU), Bozen, Italy
PY - 2025/2
Y1 - 2025/2
N2 - OBJECTIVES: Concurrence of pregnancy and cancer diagnosis is increasingly frequent in Italy. The study aimed to compare women with pregnancy-associated cancers (PACs) to those of childbearing age, focusing on fertility, induced abortion, and miscarriage.METHODS: The population-based study included women aged 15-49 years, both with and without PAC, who were residents in the area covered by the 19 participating Cancer Registries between 2003 and 2015 and identified by individual deterministic linkage with the Hospital Discharge Database.RESULTS: Overall, 2,218,139 obstetrics hospitalizations occurred, covering delivery (75%), induced abortion (14%), and miscarriage (11%). Among 2409 women with PAC, 69% gave birth, 16% had an induced abortion and 15% a miscarriage. Compared with the reference population, the fertility rate in women with PACs was steadily lower (mean values 25.7/1000 vs 37.7/1000), while induced abortion (from 359/1000 - SRR 1.99, 95%CI 1.32-3.00 - in 2003 to 147/1000 - SRR 1.11, 95%CI 0.59-2.09 - in 2015) and miscarriage ratios exhibited a decreasing trend.CONCLUSION: These results are consistent with international literature and are probably due to advancements in diagnostic and therapeutic opportunities. This is the first Italian population-based study analysing fertility and pregnancy outcomes among women with PAC based on a reliable information on cancer diagnosis.
AB - OBJECTIVES: Concurrence of pregnancy and cancer diagnosis is increasingly frequent in Italy. The study aimed to compare women with pregnancy-associated cancers (PACs) to those of childbearing age, focusing on fertility, induced abortion, and miscarriage.METHODS: The population-based study included women aged 15-49 years, both with and without PAC, who were residents in the area covered by the 19 participating Cancer Registries between 2003 and 2015 and identified by individual deterministic linkage with the Hospital Discharge Database.RESULTS: Overall, 2,218,139 obstetrics hospitalizations occurred, covering delivery (75%), induced abortion (14%), and miscarriage (11%). Among 2409 women with PAC, 69% gave birth, 16% had an induced abortion and 15% a miscarriage. Compared with the reference population, the fertility rate in women with PACs was steadily lower (mean values 25.7/1000 vs 37.7/1000), while induced abortion (from 359/1000 - SRR 1.99, 95%CI 1.32-3.00 - in 2003 to 147/1000 - SRR 1.11, 95%CI 0.59-2.09 - in 2015) and miscarriage ratios exhibited a decreasing trend.CONCLUSION: These results are consistent with international literature and are probably due to advancements in diagnostic and therapeutic opportunities. This is the first Italian population-based study analysing fertility and pregnancy outcomes among women with PAC based on a reliable information on cancer diagnosis.
KW - Humans
KW - Female
KW - Adult
KW - Abortion, Induced/statistics & numerical data
KW - Pregnancy
KW - Middle Aged
KW - Italy/epidemiology
KW - Adolescent
KW - Fertility
KW - Young Adult
KW - Neoplasms/epidemiology
KW - Abortion, Spontaneous/epidemiology
KW - Pregnancy Complications, Neoplastic/epidemiology
KW - Registries/statistics & numerical data
U2 - 10.1177/03008916241298810
DO - 10.1177/03008916241298810
M3 - Original Article
C2 - 39620650
SN - 0300-8916
VL - 111
SP - 71
EP - 78
JO - TUMORI
JF - TUMORI
IS - 1
ER -