Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function

Peter Törzsök; David Oswald; Christopher Steiner; Michael Abenhardt; Christian Ramesmayer; Ljiljana Milinovic; Bethseba Plank; Zoe Tischleritsch; Lukas Lusuardi; Susanne Deininger

doi:10.3390/jcm12227099

Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function

Peter Törzsök^* (Erstautor/-in), David Oswald (Co-Autor/-in), Christopher Steiner (Co-Autor/-in), Michael Abenhardt (Co-Autor/-in), Christian Ramesmayer (Co-Autor/-in), Ljiljana Milinovic (Co-Autor/-in), Bethseba Plank (Co-Autor/-in), Zoe Tischleritsch, Lukas Lusuardi (Co-Autor/-in), Susanne Deininger (Letztautor/-in)

^*Korrespondierende/r Autor/-in für diese Arbeit

Universitätsklinik für Urologie und Andrologie

Publikation: Beitrag in Fachzeitschrift › Originalarbeit › Begutachtung

Abstract

BACKGROUND: Our aim was to evaluate the effect of COVID-19 infection on male fertility and sexual function.

METHODS: Thirty-one patients were investigated over a mean follow-up of 90 days (22-527) after a COVID-19 infection. Erectile dysfunction (ED), blood tests for sexual hormones, semen analysis including analysis of oxidative stress (OS), as well as COVID-19 antibody titer and the nasal COVID-19 PCR test were evaluated pre- and post-infection.

RESULTS: Five patients reported a mild de novo ED (16.13%). One patient had a de novo positive mixed antiglobulin reaction test after the infection. We found no significant difference between pre-COVID-19 and post-COVID-19 spermiogram parameters (p = 0.815). OS showed no significant association with COVID-19 infection, but with pathological spermiogram categories, sperm concentration, total sperm count, testis volume, FSH and testosterone.

CONCLUSION: COVID-19 infection does not appear to affect sperm quality and OS negatively in the intermediate term. Further investigations will be needed to assess the potential long-term effects of the infection and vaccination on male sexual function and fertility.

Originalsprache	Englisch
Aufsatznummer	7099
Seitenumfang	14
Fachzeitschrift	Journal of Clinical Medicine
Jahrgang	12
Ausgabenummer	22
DOIs	https://doi.org/10.3390/jcm12227099
Publikationsstatus	Veröffentlicht - 15 Nov. 2023

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10.3390/jcm12227099

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title = "Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function",

abstract = "BACKGROUND: Our aim was to evaluate the effect of COVID-19 infection on male fertility and sexual function.METHODS: Thirty-one patients were investigated over a mean follow-up of 90 days (22-527) after a COVID-19 infection. Erectile dysfunction (ED), blood tests for sexual hormones, semen analysis including analysis of oxidative stress (OS), as well as COVID-19 antibody titer and the nasal COVID-19 PCR test were evaluated pre- and post-infection.RESULTS: Five patients reported a mild de novo ED (16.13%). One patient had a de novo positive mixed antiglobulin reaction test after the infection. We found no significant difference between pre-COVID-19 and post-COVID-19 spermiogram parameters (p = 0.815). OS showed no significant association with COVID-19 infection, but with pathological spermiogram categories, sperm concentration, total sperm count, testis volume, FSH and testosterone.CONCLUSION: COVID-19 infection does not appear to affect sperm quality and OS negatively in the intermediate term. Further investigations will be needed to assess the potential long-term effects of the infection and vaccination on male sexual function and fertility.",

author = "Peter T{\"o}rzs{\"o}k and David Oswald and Christopher Steiner and Michael Abenhardt and Christian Ramesmayer and Ljiljana Milinovic and Bethseba Plank and Zoe Tischleritsch and Lukas Lusuardi and Susanne Deininger",

note = "alle ausser Tischleritsch: Department of Urology and Andrology, Salzburg University Hospital, Paracelsus Medical University, 5020 Salzburg, Austria",

year = "2023",

month = nov,

day = "15",

doi = "10.3390/jcm12227099",

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volume = "12",

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TY - JOUR

T1 - Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function

AU - Törzsök, Peter

AU - Oswald, David

AU - Steiner, Christopher

AU - Abenhardt, Michael

AU - Ramesmayer, Christian

AU - Milinovic, Ljiljana

AU - Plank, Bethseba

AU - Tischleritsch, Zoe

AU - Lusuardi, Lukas

AU - Deininger, Susanne

N1 - alle ausser Tischleritsch: Department of Urology and Andrology, Salzburg University Hospital, Paracelsus Medical University, 5020 Salzburg, Austria

PY - 2023/11/15

Y1 - 2023/11/15

N2 - BACKGROUND: Our aim was to evaluate the effect of COVID-19 infection on male fertility and sexual function.METHODS: Thirty-one patients were investigated over a mean follow-up of 90 days (22-527) after a COVID-19 infection. Erectile dysfunction (ED), blood tests for sexual hormones, semen analysis including analysis of oxidative stress (OS), as well as COVID-19 antibody titer and the nasal COVID-19 PCR test were evaluated pre- and post-infection.RESULTS: Five patients reported a mild de novo ED (16.13%). One patient had a de novo positive mixed antiglobulin reaction test after the infection. We found no significant difference between pre-COVID-19 and post-COVID-19 spermiogram parameters (p = 0.815). OS showed no significant association with COVID-19 infection, but with pathological spermiogram categories, sperm concentration, total sperm count, testis volume, FSH and testosterone.CONCLUSION: COVID-19 infection does not appear to affect sperm quality and OS negatively in the intermediate term. Further investigations will be needed to assess the potential long-term effects of the infection and vaccination on male sexual function and fertility.

AB - BACKGROUND: Our aim was to evaluate the effect of COVID-19 infection on male fertility and sexual function.METHODS: Thirty-one patients were investigated over a mean follow-up of 90 days (22-527) after a COVID-19 infection. Erectile dysfunction (ED), blood tests for sexual hormones, semen analysis including analysis of oxidative stress (OS), as well as COVID-19 antibody titer and the nasal COVID-19 PCR test were evaluated pre- and post-infection.RESULTS: Five patients reported a mild de novo ED (16.13%). One patient had a de novo positive mixed antiglobulin reaction test after the infection. We found no significant difference between pre-COVID-19 and post-COVID-19 spermiogram parameters (p = 0.815). OS showed no significant association with COVID-19 infection, but with pathological spermiogram categories, sperm concentration, total sperm count, testis volume, FSH and testosterone.CONCLUSION: COVID-19 infection does not appear to affect sperm quality and OS negatively in the intermediate term. Further investigations will be needed to assess the potential long-term effects of the infection and vaccination on male sexual function and fertility.

U2 - 10.3390/jcm12227099

DO - 10.3390/jcm12227099

M3 - Original Article

C2 - 38002711

SN - 2077-0383

VL - 12

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 22

M1 - 7099

ER -

Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function

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