TY - JOUR
T1 - Are Genetics the Predicting Factor for the Success of Migraine Surgery?
T2 - A Report on Identical Twins
AU - Russe, Elisabeth
AU - Scharfetter, Sandra
AU - Köninger, Fabian
AU - Rinnerthaler, Mark
AU - Wechselberger, Gottfried
N1 - Lehr-KH Barmherzige Brüder Salzburg;
Russe, Köninger, Wechselberger: Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital of the Brothers of St. John of God, Paracelsus Medical University, 5020, Salzburg, Austria
PY - 2024/3
Y1 - 2024/3
N2 - Migraine affects more than 1 billion people globally, with distinct genetic variations influencing susceptibility. Thereby, genetic variations play a key role in the probability of developing migraine. However, personalized genetic analysis-based treatment options in migraine treatments are limited. Notably, surgical deactivation of extracranial trigger has shown efficacy in the treatment of migraine patients with identifiable trigger points in specific anatomical locations in the head and neck region. We present the first case of monozygotic twin sisters, both experiencing occipital and temporal-triggered migraine headaches with identical history and characteristics and without response to conservative migraine treatments. After surgical intervention, targeting the greater and lesser occipital nerves as well as auriculotemporal nerves, both twin sisters exhibited an over 99% reduction in symptoms without postoperative complications. This case suggests a potential correlation between genetic background, irrespective of environmental factors, and the effectiveness of surgical deactivation of trigger points in migraine management.
AB - Migraine affects more than 1 billion people globally, with distinct genetic variations influencing susceptibility. Thereby, genetic variations play a key role in the probability of developing migraine. However, personalized genetic analysis-based treatment options in migraine treatments are limited. Notably, surgical deactivation of extracranial trigger has shown efficacy in the treatment of migraine patients with identifiable trigger points in specific anatomical locations in the head and neck region. We present the first case of monozygotic twin sisters, both experiencing occipital and temporal-triggered migraine headaches with identical history and characteristics and without response to conservative migraine treatments. After surgical intervention, targeting the greater and lesser occipital nerves as well as auriculotemporal nerves, both twin sisters exhibited an over 99% reduction in symptoms without postoperative complications. This case suggests a potential correlation between genetic background, irrespective of environmental factors, and the effectiveness of surgical deactivation of trigger points in migraine management.
KW - Genetic variation
KW - Migraine
KW - Surgery
KW - Surgical decompression
KW - Trigger site
KW - Twin
U2 - 10.1016/j.jpra.2023.11.008
DO - 10.1016/j.jpra.2023.11.008
M3 - Case report
C2 - 38303905
SN - 2352-5878
VL - 39
SP - 223
EP - 227
JO - JPRAS open
JF - JPRAS open
ER -