A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.

Richard Hill; Ravi Kalathur; Sergio Callejas; Laura Colaço; Ricardo Brandão; Beatriz Serelde; Antonio Cebriá; Carmen Blanco-Aparicio; Joaquín Pastor; Matthias Futschik; Ana Dopazo; Wolfgang Link

doi:10.1186/s13058-014-0482-y

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.

Richard Hill, Ravi Kalathur (Co-Autor/-in), Sergio Callejas, Laura Colaço, Ricardo Brandão, Beatriz Serelde, Antonio Cebriá, Carmen Blanco-Aparicio, Joaquín Pastor, Matthias Futschik, Ana Dopazo, Wolfgang Link

Publikation: Beitrag in Fachzeitschrift › Originalarbeit › Begutachtung

35 Quellenangaben (Web of Science)

Originalsprache	Englisch
Seiten (von - bis)	482
Fachzeitschrift	BREAST CANCER RESEARCH
Jahrgang	16
Ausgabenummer	6
DOIs	https://doi.org/10.1186/s13058-014-0482-y
Publikationsstatus	Veröffentlicht - 2014

Zugriff auf Dokument

10.1186/s13058-014-0482-y

Dieses zitieren

Hill, R., Kalathur, R., Callejas, S., Colaço, L., Brandão, R., Serelde, B., Cebriá, A., Blanco-Aparicio, C., Pastor, J., Futschik, M., Dopazo, A., & Link, W. (2014). A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. BREAST CANCER RESEARCH , 16(6), 482. https://doi.org/10.1186/s13058-014-0482-y

@article{4419c53fcdf04e908449147e4980c8a0,

title = "A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.",

keywords = "NF-KAPPA-B, DNA-BINDING ACTIVITY, TRANSCRIPTION FACTORS, BREAST-CANCER, PIK3CA GENE, PHOSPHOINOSITIDE 3-KINASE, DRUG DISCOVERY, HIGH-FREQUENCY, TARGET GENES, PATHWAY",

author = "Richard Hill and Ravi Kalathur and Sergio Callejas and Laura Cola{\c c}o and Ricardo Brand{\~a}o and Beatriz Serelde and Antonio Cebri{\'a} and Carmen Blanco-Aparicio and Joaqu{\'i}n Pastor and Matthias Futschik and Ana Dopazo and Wolfgang Link",

year = "2014",

doi = "10.1186/s13058-014-0482-y",

language = "English",

volume = "16",

pages = "482",

journal = "BREAST CANCER RESEARCH ",

issn = "1465-5411",

publisher = " BioMed Central",

number = "6",

}

Hill, R, Kalathur, R, Callejas, S, Colaço, L, Brandão, R, Serelde, B, Cebriá, A, Blanco-Aparicio, C, Pastor, J, Futschik, M, Dopazo, A & Link, W 2014, 'A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.', BREAST CANCER RESEARCH , Jg. 16, Nr. 6, S. 482. https://doi.org/10.1186/s13058-014-0482-y

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. / Hill, Richard; Kalathur, Ravi (Co-Autor/-in); Callejas, Sergio et al.
in: BREAST CANCER RESEARCH , Jahrgang 16, Nr. 6, 2014, S. 482.

Publikation: Beitrag in Fachzeitschrift › Originalarbeit › Begutachtung

TY - JOUR

T1 - A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.

AU - Hill, Richard

AU - Kalathur, Ravi

AU - Callejas, Sergio

AU - Colaço, Laura

AU - Brandão, Ricardo

AU - Serelde, Beatriz

AU - Cebriá, Antonio

AU - Blanco-Aparicio, Carmen

AU - Pastor, Joaquín

AU - Futschik, Matthias

AU - Dopazo, Ana

AU - Link, Wolfgang

PY - 2014

Y1 - 2014

KW - NF-KAPPA-B

KW - DNA-BINDING ACTIVITY

KW - TRANSCRIPTION FACTORS

KW - BREAST-CANCER

KW - PIK3CA GENE

KW - PHOSPHOINOSITIDE 3-KINASE

KW - DRUG DISCOVERY

KW - HIGH-FREQUENCY

KW - TARGET GENES

KW - PATHWAY

U2 - 10.1186/s13058-014-0482-y

DO - 10.1186/s13058-014-0482-y

M3 - Original Article

C2 - 25488803

SN - 1465-5411

VL - 16

SP - 482

JO - BREAST CANCER RESEARCH

JF - BREAST CANCER RESEARCH

IS - 6

ER -